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Scientists see quadruple helix DNA for the first time

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Cambridge University scientists say they have seen four-stranded DNA at work in human cells for the first time.

 

The famous "molecule of life", which carries our genetic code, is more familiar to us as a double helix.

 

But researchers tell the journal Nature Chemistry that the "quadruple helix" is also present in our cells, and in ways that might possibly relate to cancer.

 

They suggest that control of the structures could provide novel ways to fight the disease.

 

http://www.bbc.co.uk...onment-21091066

 

 

 

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:o :o :o :o :o :o :o

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:wow: I was reading about this yesterday! The future of genetic research is brighter than ever! Hurrah !

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So what do you think this means? :hmm:

 

Apparently it's formed in an excess of Guanine. Doesn't that mean that there will also be an excess of Cytosine and thus by proxy, an excess of Adenine and Thymine? ( What with Chargaff's Parity Rules and all that)

 

Maybe it's a consequence of a mutation in the STOP codon on the mRNA, during Transcription. The tRNA/Ribosome continues past the STOP codon and on to the polyadenosine tail creating an excess of Adenine and Thymine. So, this excess is detected and to obey the parity rules, an excess of Cytosine and Guanine is formed. This could then lead to a quadruple helix?

 

 

Or does this mean Chargaff's Parity rules must be retheorised and rewritten? :o DRAMA!

 

Questions, questions, questions...

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